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GAS5 Gene

  1. Tetsuro Hirose

Published Online: 17 JAN 2011

DOI: 10.1002/9780470015902.a0005019.pub2

eLS

eLS

How to Cite

Hirose, T. 2011. GAS5 Gene. eLS. .

Author Information

  1. Biomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan

Publication History

  1. Published Online: 17 JAN 2011

Abstract

GAS5 (growth arrest-specific 5) is a nonprotein-coding small nucleolar ribonucleic acid (snoRNA) host gene. Ten box C/D snoRNAs are encoded within the 11 introns of the human GAS5 gene, whereas the spliced exons have little protein-coding potential. GAS5 has been classified as a member of the 5′ oligopyrimidine tract (5′ TOP) gene family. It is ubiquitously expressed, but the spliced GAS5 transcript is rapidly degraded in proliferating cells. Growth-dependent translation mediated by the 5′ TOP sequence present at its 5′-terminus determines the level of the GAS5 spliced transcript by a mechanism of translation-linked RNA degradation. The spliced GAS5 transcript plays a critical role in arresting cell growth and inducing apoptosis. The decreased expression of GAS5 in breast cancer suggests that GAS5 acts as a tumour suppressor. The spliced GAS5 transcript suppresses steroid-responsive transcription by direct association of the several steroid receptors and acts as a molecular decoy.

Key Concepts:

  • GAS5 is a nonprotein-coding small nucleolar RNA host gene.

  • A translation-linked mRNA decay pathway controls growth arrest-specific accumulation of GAS5 by way of its 5′-terminal oligopyrimidine tract (5′ TOP).

  • GAS5 functions to arrest cell growth and to induce apoptosis.

  • GAS5 binds to steroid hormone receptors through its 3′-terminal stem-loop structure to suppress steroid-responsive transcription.

Keywords:

  • GAS5 gene;
  • small nucleolar RNA;
  • nonprotein-coding gene;
  • 5′ TOP;
  • nonsense-mediated RNA decay;
  • molecular decoy