Published Online: 17 JAN 2011
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Hirose, T. 2011. GAS5 Gene. eLS. .
- Published Online: 17 JAN 2011
GAS5 (growth arrest-specific 5) is a nonprotein-coding small nucleolar ribonucleic acid (snoRNA) host gene. Ten box C/D snoRNAs are encoded within the 11 introns of the human GAS5 gene, whereas the spliced exons have little protein-coding potential. GAS5 has been classified as a member of the 5′ oligopyrimidine tract (5′ TOP) gene family. It is ubiquitously expressed, but the spliced GAS5 transcript is rapidly degraded in proliferating cells. Growth-dependent translation mediated by the 5′ TOP sequence present at its 5′-terminus determines the level of the GAS5 spliced transcript by a mechanism of translation-linked RNA degradation. The spliced GAS5 transcript plays a critical role in arresting cell growth and inducing apoptosis. The decreased expression of GAS5 in breast cancer suggests that GAS5 acts as a tumour suppressor. The spliced GAS5 transcript suppresses steroid-responsive transcription by direct association of the several steroid receptors and acts as a molecular decoy.
GAS5 is a nonprotein-coding small nucleolar RNA host gene.
A translation-linked mRNA decay pathway controls growth arrest-specific accumulation of GAS5 by way of its 5′-terminal oligopyrimidine tract (5′ TOP).
GAS5 functions to arrest cell growth and to induce apoptosis.
GAS5 binds to steroid hormone receptors through its 3′-terminal stem-loop structure to suppress steroid-responsive transcription.
- GAS5 gene;
- small nucleolar RNA;
- nonprotein-coding gene;
- 5′ TOP;
- nonsense-mediated RNA decay;
- molecular decoy