Standard Article

CpG Islands and DNA Methylation

  1. Francisco Antequera

Published Online: 21 DEC 2007

DOI: 10.1002/9780470015902.a0005027.pub2

eLS

eLS

How to Cite

Antequera, F. 2007. CpG Islands and DNA Methylation. eLS. .

Author Information

  1. CSIC/Universidad de Salamanca, Salamanca, Spain

Publication History

  1. Published Online: 21 DEC 2007

Abstract

Methylated CpG dinucleotides at position 5 of cytosine are associated with transcriptional repression and an inactive chromatin conformation in mammals. CpG islands are nonmethylated, CpG-rich regions of ∼1 kb that represent approximately 1% of the genome and contain promoters and deoxyribonucleic acid (DNA) replication origins.

Keywords:

  • CpG islands;
  • DNA methylation;
  • DNA methyltransferases;
  • chromatin;
  • transcription