CpG Islands and DNA Methylation
Published Online: 21 DEC 2007
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Antequera, F. 2007. CpG Islands and DNA Methylation. eLS. .
- Published Online: 21 DEC 2007
Methylated CpG dinucleotides at position 5 of cytosine are associated with transcriptional repression and an inactive chromatin conformation in mammals. CpG islands are nonmethylated, CpG-rich regions of ∼1 kb that represent approximately 1% of the genome and contain promoters and deoxyribonucleic acid (DNA) replication origins.
- CpG islands;
- DNA methylation;
- DNA methyltransferases;