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Negative Regulatory Elements (NREs)

  1. Michael Hampsey

Published Online: 21 DEC 2007

DOI: 10.1002/9780470015902.a0005030.pub2



How to Cite

Hampsey, M. 2007. Negative Regulatory Elements (NREs). eLS. .

Author Information

  1. Robert Wood Johnson Medical School, Piscataway, New Jersey, USA

Publication History

  1. Published Online: 21 DEC 2007


Negative regulatory elements (NREs) are deoxyribonucleic acid (DNA) sequences that repress gene expression. NREs can act locally to repress expression of individual genes, or globally to repress expression of an expansive chromosomal domain. In either case, NREs act as binding sites for specific proteins, which in turn interact with other factors either to block recruitment of ribonucleic acid (RNA) polymerase or to facilitate formation of heterochromatin.


  • chromatin;
  • repression;
  • silencing;
  • transcription