Negative Regulatory Elements (NREs)
Published Online: 21 DEC 2007
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Hampsey, M. 2007. Negative Regulatory Elements (NREs). eLS. .
- Published Online: 21 DEC 2007
Negative regulatory elements (NREs) are deoxyribonucleic acid (DNA) sequences that repress gene expression. NREs can act locally to repress expression of individual genes, or globally to repress expression of an expansive chromosomal domain. In either case, NREs act as binding sites for specific proteins, which in turn interact with other factors either to block recruitment of ribonucleic acid (RNA) polymerase or to facilitate formation of heterochromatin.