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Zinc-finger Genes

  1. Richard P Grant,
  2. M Crossley,
  3. Joel P Mackay

Published Online: 28 SEP 2007

DOI: 10.1002/9780470015902.a0005047.pub2



How to Cite

Grant, R. P., Crossley, M. and Mackay, J. P. 2007. Zinc-finger Genes. eLS. .

Author Information

  1. University of Sydney, Australia

Publication History

  1. Published Online: 28 SEP 2007


Zinc-fingers (ZnFs) are small protein domains stabilized by one or more zinc ions. ZnF proteins are abundant in higher eukaryotes, and many contain multiple ZnF domains. Initially thought to be peculiar to transcription factors and other deoxyribonucleic acid (DNA)-binding proteins, these domains can also interact with other proteins, ribonucleic acid (RNA) and lipids, implicating them in a mélange of biological processes.


  • zinc-finger;
  • DNA-binding protein;
  • protein–protein interactions;
  • cysteine;
  • histidine