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Insertion and Deletion of Exons during Human Gene Evolution

  1. David N Cooper

Published Online: 28 SEP 2007

DOI: 10.1002/9780470015902.a0005088.pub2

eLS

eLS

How to Cite

Cooper, D. N. 2007. Insertion and Deletion of Exons during Human Gene Evolution. eLS. .

Author Information

  1. Cardiff University, Cardiff, UK

Publication History

  1. Published Online: 28 SEP 2007

Abstract

During the evolution of human genes, exons have been both acquired and lost. The study of the structure of orthologous mammalian genes provides numerous examples of the gain or loss of exons by a variety of different mechanisms.

Keywords:

  • exon deletion;
  • exon insertion;
  • exon duplication/amplification;
  • exon shuffling;
  • LINE element-mediated recombination;
  • alternative splicing;
  • pseudoexons