Standard Article

Phylogenetic Footprinting

  1. Wyeth W Wasserman1,
  2. Wynand Alkema2

Published Online: 30 APR 2008

DOI: 10.1002/9780470015902.a0005091.pub2



How to Cite

Wasserman, W. W. and Alkema, W. 2008. Phylogenetic Footprinting. eLS. .

Author Information

  1. 1

    University of British Columbia, Vancouver, British Columbia, Canada

  2. 2

    Karoliniska Institutet, Stockholm, Sweden

Publication History

  1. Published Online: 30 APR 2008


Phylogenetic footprinting is a method for the comparative analysis of orthologous gene sequences. Based on the expectation that sequences under selective pressure will be conserved over moderate periods of evolutionary time, phylogenetic footprinting is one means to identify gene segments with a specific function.


  • phylogenetic footprinting;
  • evolution;
  • sequence comparison;
  • transcription