Synonymous and Nonsynonymous Rates
Published Online: 21 DEC 2007
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Yi, S. 2007. Synonymous and Nonsynonymous Rates. eLS. .
- Published Online: 21 DEC 2007
When comparing protein-coding DNA sequences between species, it is useful to distinguish between synonymous (silent) substitutions and nonsynonymous (amino-acid changing) substitutions. Because the two types of change are under different intensities of selective constraints, comparing their rates provides insights into the mechanisms of evolution of the gene under study.
- coding regions;
- nucleotide substitution;
- degenerate code;
- functional constraints;
- positive selection