Standard Article

GC-rich Isochores in the Interphase Nucleus

  1. Salvatore Saccone1,
  2. Giorgio Bernardi2

Published Online: 15 JUL 2008

DOI: 10.1002/9780470015902.a0005123.pub2



How to Cite

Saccone, S. and Bernardi, G. 2008. GC-rich Isochores in the Interphase Nucleus. eLS. .

Author Information

  1. 1

    University of Catania, Catania, Italy

  2. 2

    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Napoli, Italy

Publication History

  1. Published Online: 15 JUL 2008

This is not the most recent version of the article. View current version (16 MAY 2016)


In the interphase nuclei of human and other warm-blooded vertebrates, the gene-richest chromosomal regions are located in more internal positions and display much more spread-out conformations than the gene-poorest regions, the latter also showing more peripheral nuclear locations.


  • isochores;
  • natural selection;
  • chromatin organization;
  • cell nucleus;
  • gene density;
  • chromosomal bands