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Tissue-specific Locus Control: Structure and Function

  1. Constanze Bonifer

Published Online: 28 SEP 2007

DOI: 10.1002/9780470015902.a0005292.pub2



How to Cite

Bonifer, C. 2007. Tissue-specific Locus Control: Structure and Function. eLS. .

Author Information

  1. University of Leeds, Leeds, UK

Publication History

  1. Published Online: 28 SEP 2007


All developmental processes involve decisions in which the developmental fate of precursor cells is restricted to a single lineage by establishing a unique gene expression pattern. The activation at each of these gene loci involves restructuring chromatin as a necessary prerequisite for the assembly of the transcription apparatus. Tissue-specific locus activation is controlled by the interplay between sequence-specific transcription factors, chromatin-modifying activities and basic chromatin components.


  • gene locus activation;
  • transcriptional control elements;
  • histones;
  • nucleosomes;
  • chromatin;
  • position effect;
  • globin