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Comparative Human Genomics

  1. I King Jordan1,
  2. Eugene V Koonin2

Published Online: 15 JUL 2008

DOI: 10.1002/9780470015902.a0005296.pub2



How to Cite

Jordan, I. K. and Koonin, E. V. 2008. Comparative Human Genomics. eLS. .

Author Information

  1. 1

    Georgia Institute of Technology, Atlanta, Georgia, USA

  2. 2

    National Institutes of Health, Bethesda, Maryland, USA

Publication History

  1. Published Online: 15 JUL 2008


Comparative genomics involves the comparison of features of completely sequenced (or nearly so) genomes. Comparative sequence analyses facilitate both the functional annotation of genomes and whole-genome approaches to evolutionary issues. We present a review of the field of comparative genomics and point out how the comparative approach can be used to help better understand the human genome sequence.


  • molecular evolution;
  • natural selection;
  • transposable elements;
  • horizontal gene transfer;
  • noncoding DNA;
  • individual genomics