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Long Interspersed Nuclear Elements (LINEs): Evolution

  1. Anthony V Furano1,
  2. Stéphane Boissinot2

Published Online: 15 JUL 2008

DOI: 10.1002/9780470015902.a0005304.pub2



How to Cite

Furano, A. V. and Boissinot, S. 2008. Long Interspersed Nuclear Elements (LINEs): Evolution. eLS. .

Author Information

  1. 1

    National Institutes of Health, Bethesda, Maryland, USA

  2. 2

    City University of New York, Flushing, New York, USA

Publication History

  1. Published Online: 15 JUL 2008


LINE-1 (long interspersed nuclear element-1, L1) repeated deoxyribonucleic acid (DNA) elements are non-long terminal repeat (LTR) group of retrotransposons that replicate by copying (reverse transcribing) their ribonucleic acid (RNA) transcript into genomic DNA. LINE-1 elements, which can also copy other RNAs into genomic DNA, are the dominant (and in some species the only) active clade of retrotransposons in mammals, where they have been replicating and evolving since before the mammalian radiation approximately 100 million years ago.


  • LINE-1;
  • L1;
  • retrotransposon;
  • evolution;
  • human