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Linkage Disequilibrium

  1. Peter JP Croucher

Published Online: 14 MAR 2008

DOI: 10.1002/9780470015902.a0005427.pub2

eLS

eLS

How to Cite

Croucher, P. J. 2008. Linkage Disequilibrium. eLS. .

Author Information

  1. University of California at Berkeley, Berkeley, California, USA

Publication History

  1. Published Online: 14 MAR 2008

This is not the most recent version of the article. View current version (15 APR 2013)

Abstract

When two or more polymorphic loci are studied in a population, the interaction between the loci is often expressed in terms of linkage disequilibrium (LD). The loci are in LD if their respective alleles do not associate independently (randomly). The degree of over- or underrepresentation of the expected haplotypes measures the extent of LD. Recombination acts to reduce LD.

Keywords:

  • haplotype;
  • gametic phase;
  • mutation;
  • recombination;
  • population