Genetics of Large Populations and Association Studies
Published Online: 14 MAR 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Garnier-Géré, P. H. and Chikhi, L. 2008. Genetics of Large Populations and Association Studies. eLS. .
- Published Online: 14 MAR 2008
This is not the most recent version of the article. View current version (15 NOV 2013)
Association studies aim to discover the genetic basis of genetic diseases or drug responses through the comparison of unrelated affected and nonaffected individuals in large populations assumed to be at Hardy–Weinberg equilibrium (HWE). The HWE principle and the main causes of departures are first described with a focus on population stratification (Wahlund effect), which is one of the major problems in association studies. Recent statistical methods developed to detect and control for it are briefly reviewed.
- Hardy–Weinberg equilibrium;
- Wahlund effect;
- population stratification;
- linkage disequilibrium;
- association studies