Fixation Probabilities and Times
Published Online: 13 JUN 2013
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Otto, S. P. and Whitlock, M. C. 2013. Fixation Probabilities and Times. eLS. .
- Published Online: 13 JUN 2013
The fixation probability of an allele is the probability that it will eventually be the ancestor of all the alleles within a population at that locus. Population genetics theory has demonstrated that the probability of fixation is approximately proportional to the selection coefficient of a weak beneficial mutation, because such mutations are susceptible to stochastic loss while being rare despite their advantage. The time to fixation is the number of generations that it takes for an allele to progress from its initial frequency to fixation. This time is inversely proportional to the selection coefficient of a beneficial allele. Interestingly, though deleterious alleles are much less likely to fix, the time that they take to do so is, on average, the same as for a beneficial allele with the same magnitude of selective effect.
The fixation probability of an allele is the probability that it will eventually be the ancestor of all the alleles within a population at that locus.
Even beneficial mutations may not fix within a population.
The fixation probability of a beneficial allele is approximately proportional to its selection coefficient.
Deleterious mutations are unlikely to fix, but they can fix if their selective disadvantage is sufficiently weak and the population size sufficiently small.
The time for a new allele to fix within a population is inversely proportional to the magnitude of selection for both beneficial and deleterious alleles.
- branching process;
- probability of fixation;
- time to fixation