X-chromosome Inactivation and Disease
Published Online: 16 JUL 2007
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Lyon, M. F. 2007. X-chromosome Inactivation and Disease. eLS. .
- Published Online: 16 JUL 2007
X-chromosome inactivation is the phenomenon in which one of the two X chromosomes in every somatic cell of female mammals becomes transcriptionally inactive early in embryonic development. This has the result of equalizing the effective gene dosage of X-linked genes in chromosomally XX females and XY males, and is hence known as a dosage-compensation mechanism. In humans, X-chromosome inactivation has implications for the effects seen in diseases due either to X-linked genes or to numerical or structural anomalies of the X-chromosome.
- X-linked diseases;
- X-chromosome aneuploidy;
- X-autosome translocations;
- XIST gene;
- X-inactivation centre