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Pharmacogenetics and Pharmacogenomics

  1. Daniel W Nebert

Published Online: 30 APR 2008

DOI: 10.1002/9780470015902.a0005558.pub2

eLS

eLS

How to Cite

Nebert, D. W. 2008. Pharmacogenetics and Pharmacogenomics. eLS. .

Author Information

  1. University of Cincinnati Medical Center, Cincinnati, Ohio, USA

Publication History

  1. Published Online: 30 APR 2008

Abstract

Between 1930 and 1990, several dozen high-penetrance predominantly monogenic (hPpM) disorders in drug metabolism were identified and characterized, leading many to expect that the field of pharmacogenetics would very soon be able to provide us with ‘individualized drug therapy’. However, then came the Human Genome Project and the field of pharmacogenomics. We now realize that the genome is exceedingly complex and that the likelihood of ever achieving individualized drug therapy – for every person and every drug – is not scientifically or financially feasible. Perhaps genomics – in combination with transcriptomics, proteomics and metabonomics – will provide some degree of success, within the next several decades.

Keywords:

  • drug metabolism;
  • transporters;
  • receptors;
  • signal transduction pathways;
  • polymorphisms;
  • human populations