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Down Syndrome: Antenatal Screening

  1. Tim Reynolds

Published Online: 28 SEP 2007

DOI: 10.1002/9780470015902.a0005635.pub2

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How to Cite

Reynolds, T. 2007. Down Syndrome: Antenatal Screening. eLS. .

Author Information

  1. Queen's Hospital, Burton-on-Trent, UK

Publication History

  1. Published Online: 28 SEP 2007

This is not the most recent version of the article. View current version (15 AUG 2014)

Abstract

Antenatal screening for Down syndrome involves the application of noninvasive measurements (blood tests or ultrasound scanning) taken early in pregnancy to determine whether a fetus is likely to be affected by Down syndrome, to allow identification of a small proportion of pregnancies (usually around 5%) in which to carry out an invasive diagnostic test (chorionic villus sampling or amniocentesis). Restriction of the invasive test is advisable because there is a risk of iatrogenic fetal loss as a result of the diagnostic test.

Keywords:

  • Down syndrome;
  • screening;
  • trisomy 21;
  • ethics