Gene Distribution in Human Chromosomes
Published Online: 15 JUL 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Bernardi, G. and Saccone, S. 2008. Gene Distribution in Human Chromosomes. eLS. .
- Published Online: 15 JUL 2008
The distribution of genes in the human genome is strikingly nonuniform. Gene density is very high in GC (G, guanine; C, cytosine)-rich isochores and very low in GC-poor isochores (isochores are long deoxyribonucleic acid (DNA) regions characterized by a fairly homogeneous GC level). Since GC-rich and GC-poor isochores can be localized on human chromosomes, this ‘chromosomal compositional mapping’ provides information on the distribution of genes on chromosomes. The completion of the human genome sequence and the mapping of isochores on chromosomes have recently confirmed these results.
- chromosomal bands;
- telomeric bands;
- gene density;
- in situ hybridization