Published Online: 30 APR 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Hore, T. A., Wakefield, M. J. and Graves, J. A. 2008. X-chromosome Inactivation. eLS. .
- Published Online: 30 APR 2008
X-chromosome inactivation is an epigenetic process that silences the majority of genes on one of the two X-chromosomes in female mammals. This silencing effectively equalizes dosage of X-linked genes in females with that of males, who only possess one X-chromosome and a sex-determining Y-chromosome.
- dosage compensation;
- chromatin modification;
- deoxyribonucleic acid methylation;
- sex chromosomes;
- transcriptional regulation