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Y Chromosome

  1. Chris Tyler-Smith

Published Online: 21 DEC 2007

DOI: 10.1002/9780470015902.a0005796.pub2



How to Cite

Tyler-Smith, C. 2007. Y Chromosome. eLS. .

Author Information

  1. The Wellcome Trust Sanger Institute, Hinxton, UK

Publication History

  1. Published Online: 21 DEC 2007


The Y chromosome has a key role in human sex determination and carries the male sex-determining gene, SRY. As a consequence of this function, it has unique genetic properties such as a large region that is haploid and escapes meiotic recombination, and unique physical properties such as low gene but high repeated sequence density. The sequence of the euchromatic half of the chromosome has been determined in one individual, and this is accelerating systematic studies of both sequence and structural variation in the population and their phenotypic consequences.


  • Y chromosomal structure;
  • male sex determination;
  • SRY;
  • male fertility;
  • AZF