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Comparative Cytogenetics Technologies

  1. Stefan Müller,
  2. Johannes Wienberg

Published Online: 21 DEC 2007

DOI: 10.1002/9780470015902.a0005802.pub2

eLS

eLS

How to Cite

Müller, S. and Wienberg, J. 2007. Comparative Cytogenetics Technologies. eLS. .

Author Information

  1. Ludwig Maximilians University, Munich, Germany

Publication History

  1. Published Online: 21 DEC 2007

Abstract

During the last two decades, comparative cytogenetics has developed from a specialized discipline to a highly dynamic field of research. Major technological advancements have driven this development, combined with the increasing awareness that many aspects of human genome function can be better understood in an evolutionary context. Comparative chromosome and genome analysis is providing a valuable tool in various fields of basic and applied genome research, such as the identification of candidate gene loci in biomedical animal models, or for the understanding of relationships between chromosome evolution and disease. This article provides a summary of recent technical developments in the field of comparative cytogenetics and genomics, together with selected examples for their applications.

Keywords:

  • cross-species chromosome painting;
  • Zoo-FISH;
  • comparative mapping;
  • DNA micro-array;
  • chromosomal homology;
  • phylogenetic analysis