Comparative Cytogenetics Technologies
Published Online: 21 DEC 2007
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Müller, S. and Wienberg, J. 2007. Comparative Cytogenetics Technologies. eLS. .
- Published Online: 21 DEC 2007
During the last two decades, comparative cytogenetics has developed from a specialized discipline to a highly dynamic field of research. Major technological advancements have driven this development, combined with the increasing awareness that many aspects of human genome function can be better understood in an evolutionary context. Comparative chromosome and genome analysis is providing a valuable tool in various fields of basic and applied genome research, such as the identification of candidate gene loci in biomedical animal models, or for the understanding of relationships between chromosome evolution and disease. This article provides a summary of recent technical developments in the field of comparative cytogenetics and genomics, together with selected examples for their applications.
- cross-species chromosome painting;
- comparative mapping;
- DNA micro-array;
- chromosomal homology;
- phylogenetic analysis