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Chromosomal Rearrangements in Primates

  1. Roscoe Stanyon,
  2. Francesca Bigoni

Published Online: 15 JUL 2008

DOI: 10.1002/9780470015902.a0005805.pub2

eLS

eLS

How to Cite

Stanyon, R. and Bigoni, F. 2008. Chromosomal Rearrangements in Primates. eLS. .

Author Information

  1. University of Florence, Via del Proconsolo, Florence, Italy

Publication History

  1. Published Online: 15 JUL 2008

This is not the most recent version of the article. View current version (14 SEP 2015)

Abstract

Comparative molecular cytogenetics techniques allow us to trace the chromosome rearrangements which have occurred during primate and human evolution. Technique such as fluorescence in situ hybridization (FISH) of whole chromosome paints (WCP) allows us to track interchromosomal rearrangements (translocations). FISH with smaller probes such as bacterial artificial chromosomes (BAC) allows us to study intrachromosomal rearrangements such as inversions. These data show that human chromosomes are amazingly similar to those of great apes and most Old World monkeys. Human chromosomes can be derived from the ancestral primate karyotype by a limited number of rearrangements.

Keywords:

  • FISH;
  • BAC;
  • synteny;
  • translocation;
  • marker order