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Cytogenetic and Physical Chromosomal Maps: Integration

  1. Ilan R Kirsch,
  2. Thomas Ried

Published Online: 15 SEP 2006

DOI: 10.1002/9780470015902.a0005918

eLS

eLS

How to Cite

Kirsch, I. R. and Ried, T. 2006. Cytogenetic and Physical Chromosomal Maps: Integration. eLS. .

Author Information

  1. National Cancer Institute, Bethesda, Maryland, USA

Publication History

  1. Published Online: 15 SEP 2006

Abstract

It is now possible to link a cytogenetic location directly with the sequence of the human genome. This is accomplished by using a toolset consisting of high-resolution fluorescent in situ hybridization-mapped and sequenced bacterial artificial chromosome clones distributed at 1–2 Mb intervals across the genome. This toolset is available from a commercial repository and is searchable in publicly available databases cross-referenced to extant information on cancer-associated chromosomal aberrations.

Keywords:

  • cytogenetics;
  • bacterial artificial chromosomes;
  • fluorescent in situ hybridization;
  • genome sequence;
  • database