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Clustering of Highly Expressed Genes in the Human Genome

  1. Hinco J Gierman,
  2. Rogier Versteeg

Published Online: 30 APR 2008

DOI: 10.1002/9780470015902.a0005931.pub2

eLS

eLS

How to Cite

Gierman, H. J. and Versteeg, R. 2008. Clustering of Highly Expressed Genes in the Human Genome. eLS. .

Author Information

  1. University of Amsterdam, Amsterdam, The Netherlands

Publication History

  1. Published Online: 30 APR 2008

Abstract

A dual mechanism of gene regulation exists in the human genome: Transcription factors determine whether a gene will be expressed and establish a basic level of transcription. In addition, the chromosomal domain in which a gene is positioned exerts a substantial effect and potentiates the ultimate expression level.

Keywords:

  • chromosomal domains;
  • gene expression;
  • transcription;
  • genome organization;
  • gene clustering