Standard Article

mRNA Turnover

  1. Philip Mitchell

Published Online: 15 SEP 2006

DOI: 10.1002/9780470015902.a0005981



How to Cite

Mitchell, P. 2006. mRNA Turnover. eLS. .

Author Information

  1. University of Edinburgh, Edinburgh, UK

Publication History

  1. Published Online: 15 SEP 2006


Messenger ribonucleic acid (mRNA) degradation mechanisms provide important regulatory steps in the control of eukaryotic gene expression. Although major recent advances have been made in our understanding of cytoplasmic mRNA turnover in mammalian cells, we are only just beginning to unravel the mechanisms of RNA turnover in the cell nucleus.


  • exonuclease;
  • exosome;
  • nonsense-mediated decay;
  • deadenylase;
  • RNA helicase