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Translation Initiation: Molecular Mechanisms in Eukaryotes

  1. Christopher UT Hellen1,
  2. Tatyana V Pestova1,2

Published Online: 15 SEP 2006

DOI: 10.1002/9780470015902.a0005994



How to Cite

Hellen, C. U. and Pestova, T. V. 2006. Translation Initiation: Molecular Mechanisms in Eukaryotes. eLS. .

Author Information

  1. 1

    State University of New York, Brooklyn, New York, USA

  2. 2

    Moscow State University, Moscow, Russia

Publication History

  1. Published Online: 15 SEP 2006


Initiation is the first phase in protein synthesis, during which eukaryotic initiation factors assemble an 80S ribosome at an initiation codon of a messenger RNA (mRNA) such that this triplet is base-paired to the CAU anticodon of aminoacylated initiator methionyl-transfer RNA in the ribosomal peptidyl site. Initiation is followed by the elongation phase, in which the 80S ribosome moves along the mRNA, translating the open reading frame into protein.


  • eukaryotic translation initiation factor;
  • messenger ribonucleic acid;
  • ribosome;
  • transfer ribonucleic acid;
  • translation initiation