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Translation Initiation: Molecular Mechanisms in Eukaryotes

  1. Christopher UT Hellen1,
  2. Tatyana V Pestova1,2

Published Online: 15 SEP 2006

DOI: 10.1002/9780470015902.a0005994

eLS

eLS

How to Cite

Hellen, C. U. and Pestova, T. V. 2006. Translation Initiation: Molecular Mechanisms in Eukaryotes. eLS. .

Author Information

  1. 1

    State University of New York, Brooklyn, New York, USA

  2. 2

    Moscow State University, Moscow, Russia

Publication History

  1. Published Online: 15 SEP 2006

Abstract

Initiation is the first phase in protein synthesis, during which eukaryotic initiation factors assemble an 80S ribosome at an initiation codon of a messenger RNA (mRNA) such that this triplet is base-paired to the CAU anticodon of aminoacylated initiator methionyl-transfer RNA in the ribosomal peptidyl site. Initiation is followed by the elongation phase, in which the 80S ribosome moves along the mRNA, translating the open reading frame into protein.

Keywords:

  • eukaryotic translation initiation factor;
  • messenger ribonucleic acid;
  • ribosome;
  • transfer ribonucleic acid;
  • translation initiation