Translation Initiation: Molecular Mechanisms in Eukaryotes
Published Online: 15 SEP 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Hellen, C. U. and Pestova, T. V. 2006. Translation Initiation: Molecular Mechanisms in Eukaryotes. eLS. .
- Published Online: 15 SEP 2006
Initiation is the first phase in protein synthesis, during which eukaryotic initiation factors assemble an 80S ribosome at an initiation codon of a messenger RNA (mRNA) such that this triplet is base-paired to the CAU anticodon of aminoacylated initiator methionyl-transfer RNA in the ribosomal peptidyl site. Initiation is followed by the elongation phase, in which the 80S ribosome moves along the mRNA, translating the open reading frame into protein.
- eukaryotic translation initiation factor;
- messenger ribonucleic acid;
- transfer ribonucleic acid;
- translation initiation