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Variable Drug Response: Genetic Evaluation

  1. Ashraf G Madian,
  2. Richard Baker Jones

Published Online: 18 OCT 2013

DOI: 10.1002/9780470015902.a0006001.pub2



How to Cite

Madian, A. G. and Baker Jones, R. 2013. Variable Drug Response: Genetic Evaluation. eLS. .

Author Information

  1. University of Chicago, Chicago, Illinois, USA

Publication History

  1. Published Online: 18 OCT 2013


The field of pharmacogenomics attempts to evaluate the contribution of genetic variants to drug sensitivity and adverse effects. Over the past decade, the pharmacogenomics field has evolved from using candidate gene approaches to application of genome-wide approaches for the identification of genetic variants associated with drug responses. Understanding the underlying biology of these associations as well as their translation into clinical practice represents a major ongoing and future challenge.

Key Concepts:

  • A discussion on pharmacogenomics studies on drug response and adverse drug reactions.

  • History of pharmacogenomics

  • The ethnic component of pharmacogenomics

  • The impact of genetics on drug response

  • The impact of genetics on adverse drug reactions

  • Clinical implementation of pharmacogenomics


  • pharmacogenomics;
  • personalised medicine;
  • pharmacoethnicity;
  • drug response;
  • adverse drug reactions