Variable Drug Response: Genetic Evaluation
Published Online: 18 OCT 2013
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Madian, A. G. and Baker Jones, R. 2013. Variable Drug Response: Genetic Evaluation. eLS. .
- Published Online: 18 OCT 2013
The field of pharmacogenomics attempts to evaluate the contribution of genetic variants to drug sensitivity and adverse effects. Over the past decade, the pharmacogenomics field has evolved from using candidate gene approaches to application of genome-wide approaches for the identification of genetic variants associated with drug responses. Understanding the underlying biology of these associations as well as their translation into clinical practice represents a major ongoing and future challenge.
A discussion on pharmacogenomics studies on drug response and adverse drug reactions.
History of pharmacogenomics
The ethnic component of pharmacogenomics
The impact of genetics on drug response
The impact of genetics on adverse drug reactions
Clinical implementation of pharmacogenomics
- personalised medicine;
- drug response;
- adverse drug reactions