Standard Article

Oncogenes

  1. Randy Todd1,
  2. Karl Munger2

Published Online: 15 SEP 2006

DOI: 10.1002/9780470015902.a0006006

eLS

eLS

How to Cite

Todd, R. and Munger, K. 2006. Oncogenes. eLS. .

Author Information

  1. 1

    Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, Massachusetts, USA

  2. 2

    Harvard Medical School, Boston, Massachusetts, USA

Publication History

  1. Published Online: 15 SEP 2006

Abstract

Oncogenes override normal regulatory controls and contribute to the malignant transformation of a cell. Mutation of their normal cellular counterparts (proto-oncogenes) leads to a quantitative or qualitative alteration of cellular pathway members important for cancer formation and spread.

Keywords:

  • carcinogenesis;
  • proto-oncogene;
  • amplification;
  • translocation;
  • point mutation