Standard Article

Telomeres and Telomerase in Ageing and Cancer

  1. Michel M Ouellette,
  2. Kyung Hyun Choi

Published Online: 28 SEP 2007

DOI: 10.1002/9780470015902.a0006067.pub2

eLS

eLS

How to Cite

Ouellette, M. M. and Choi, K. H. 2007. Telomeres and Telomerase in Ageing and Cancer. eLS. .

Author Information

  1. University of Nebraska Medical Center, Omaha, Nebraska, USA

Publication History

  1. Published Online: 28 SEP 2007

Abstract

Telomeres protect the ends of chromosomes and shorten each time somatic human cells divide. As a consequence, cells enter senescence after a limited number of divisions. The enzyme telomerase expressed in cancer cells and renewal tissues can prevent the shortening of telomeres and extend cellular lifespan.

Keywords:

  • telomere;
  • telomerase;
  • cancer;
  • ageing