Thrifty Genotype Hypothesis and Complex Genetic Disease
Published Online: 14 MAR 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Vardi, P. and Bloch, K. 2008. Thrifty Genotype Hypothesis and Complex Genetic Disease. eLS. .
- Published Online: 14 MAR 2008
Thrifty genes might be responsible for the appearance and increasing frequency of diseases that were uncommon before the emergence of the affluent Western life style. Evolutionary selection of such genes enabled metabolic adaptation to disadvantageous conditions, but now thrifty gene expression is detrimental to health.
- modern old-age diseases;
- polygenic diseases;