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Transcriptional Channelopathies of the Nervous System

  1. Stephen G Waxman1,2

Published Online: 15 SEP 2006

DOI: 10.1002/9780470015902.a0006086

eLS

eLS

How to Cite

Waxman, S. G. 2006. Transcriptional Channelopathies of the Nervous System. eLS. .

Author Information

  1. 1

    Yale School of Medicine, New Haven, Connecticut, USA

  2. 2

    VA Hospital, West Haven, Connecticut, USA

Publication History

  1. Published Online: 15 SEP 2006

Abstract

Recent studies have provided evidence for the existence of transcriptional channelopathies, which result from dysregulated expression of nonmutated channel genes. Examples of this new class of disorders are provided by peripheral nerve injury which triggers spinal sensory neurons to turn off some previously active sodium channel genes and turn on other previously silent sodium channel genes, a set of changes that can produce hyperexcitability of these cells, and by changes in sodium channel gene expression that may perturb cerebellar function in multiple sclerosis.

Keywords:

  • ion channel;
  • gene transcription;
  • neurological disease;
  • voltage-gated sodium channel