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Systemic Lupus Erythematosus: Genetic and Epigenetic View

  1. Swapan K Nath2,
  2. Amr H Sawalha1

Published Online: 15 JUL 2008

DOI: 10.1002/9780470015902.a0006092

eLS

eLS

How to Cite

Nath, S. K. and Sawalha, A. H. 2008. Systemic Lupus Erythematosus: Genetic and Epigenetic View. eLS. .

Author Information

  1. 1

    Veterans Affairs Medical Center, Oklahoma City, Oklahoma, USA

  2. 2

    Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA

Publication History

  1. Published Online: 15 JUL 2008

Abstract

Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with complex aetiology, in which susceptibility is determined by the combination of genetic, environmental, epigenetic and stochastic factors. SLE is very heterogeneous in its clinical manifestations and the presence of different autoantibodies may predict different set of clinical outcome. However, despite considerable accumulated knowledge, the detailed pathogenesis of SLE still remains unknown. Several studies have indicated the importance of deoxyribonucleic acid (DNA) hypomethylation in the aetiology of SLE. Recent advances in high-throughput genotyping technologies and high-density genetic association studies have identified and replicated many SLE susceptibility genes in different populations. In this article, we outline our current understanding of some genetic and epigenetic aspects of SLE.

Keywords:

  • SLE;
  • Candidate gene;
  • Linkage;
  • Association;
  • Epigenetic;
  • DNA methylation