Published Online: 30 APR 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Silverman, G. A., Askew, D. J., Irving, J. A., Luke, C. J., Kaiserman, D., Bird, P. I. and Whisstock, J. C. 2008. Serpins: Evolution. eLS. .
- Published Online: 30 APR 2008
The serpin superfamily of serine (and cysteine) proteinase inhibitors contains over 750 members represented in Bacteria, Archaea and Eukarya. All members of the serpin family share a unique tertiary structure that is critical to both inhibitory and noninhibitory functions. Serpins are involved in a vast array of biological processes, including the regulation of thrombosis, fibrinolysis and inflammation, and host defense.
- serine proteinase inhibitor;
- cysteine proteinase inhibitor;