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Evolutionarily Conserved Noncoding DNA

  1. Anil G Jegga,
  2. Bruce J Aronow

Published Online: 30 APR 2008

DOI: 10.1002/9780470015902.a0006126.pub2

eLS

eLS

How to Cite

Jegga, A. G. and Aronow, B. J. 2008. Evolutionarily Conserved Noncoding DNA. eLS. .

Author Information

  1. University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

Publication History

  1. Published Online: 30 APR 2008

This is not the most recent version of the article. View current version (19 SEP 2013)

Abstract

The availability of increasingly complete and accurate genomic sequence data from evolutionarily separated species – as well as diverse strains and ethnic variants within species – is providing an unprecedented opportunity to identify potentially functional regions within genomic noncoding deoxyribonucleic acid (DNA). A variety of bioinformatics tools enable genome-wide detection, characterization and visualization of highly conserved sequences and the occurrence of potentially functional elements within both the conserved and evolved elements.

Keywords:

  • phylogenetic conservation;
  • Noncoding DNA;
  • regulatory region;
  • cis-elements;
  • promoter;
  • enhancer