Dosage Compensation Mechanisms: Evolution
Published Online: 14 MAR 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Marín, I. 2008. Dosage Compensation Mechanisms: Evolution. eLS. .
- Published Online: 14 MAR 2008
Degeneration of sex-limited chromosomes favours the emergence of dosage compensation mechanisms able to equalize in both sexes the amount of products derived from sex-linked genes. These mechanisms are understood in detail in the fly Drosophila melanogaster, the nematode Caenorhabditis elegans and in eutherian mammals. The three systems, biochemically and evolutionarily unrelated, share a common logic.
- chromosome degeneration;
- sex chromosomes;
- transcription regulation;