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Fibroblast Growth Factors: Evolution

  1. David M Ornitz

Published Online: 21 DEC 2007

DOI: 10.1002/9780470015902.a0006134.pub2

eLS

eLS

How to Cite

Ornitz, D. M. 2007. Fibroblast Growth Factors: Evolution. eLS. .

Author Information

  1. Washington University School of Medicine, St. Louis, Missouri, USA

Publication History

  1. Published Online: 21 DEC 2007

Abstract

Fibroblast growth factors (FGFs) and their receptors (FGF receptors) constitute a signalling system conserved throughout animal evolution. Most members of the FGF family signal across adjacent tissue boundaries and are essential for a variety of developmental and physiological processes. One subfamily of vertebrate FGFs, that may have originated in primitive chordates, appears to have evolved novel functions within neurons. Another subfamily of FGFs has acquired hormone-like properties, regulating physiological processes in the adult.

Keywords:

  • fibroblast growth factor (FGF);
  • FGF receptor tyrosine kinase (FGFR);
  • endocrine hormone;
  • heparin/heparan sulfate;
  • neurophysiology;
  • klotho