Standard Article

Low-density Lipoprotein Receptor (LDLR) Family: Genetics and Evolution

  1. Wolfgang Johann Schneider

Published Online: 30 APR 2008

DOI: 10.1002/9780470015902.a0006138.pub2

eLS

eLS

How to Cite

Schneider, W. J. 2008. Low-density Lipoprotein Receptor (LDLR) Family: Genetics and Evolution. eLS. .

Author Information

  1. University of Vienna, Vienna, Austria

Publication History

  1. Published Online: 30 APR 2008

Abstract

The low-density lipoprotein receptor family comprises a large and growing number of genes, whose products contain a characteristic set of structural domains. Attempts to delineate the evolutionary history of this gene family must take into consideration newly discovered functions, ranging from ligand binding by the extracellular domains to signal transduction through the cytoplasmic regions of the receptors.

Keywords:

  • low-density lipoprotein;
  • gene family;
  • receptor;
  • ligand binding;
  • signal transduction