Standard Article

Proteases: Evolution

  1. Christopher Southan

Published Online: 30 APR 2008

DOI: 10.1002/9780470015902.a0006141.pub2



How to Cite

Southan, C. 2008. Proteases: Evolution. eLS. .

Author Information

  1. Oxford GlycoSciences Ltd, Abingdon, UK

Publication History

  1. Published Online: 30 APR 2008


Human proteases have diverse fold structures, catalytic mechanisms, biochemical functions and evolutionary origins. Most arose by gene duplication, but some arose by horizontal transfer from prokaryotes. Adaptation and diversification of their biological roles have resulted from shifts in substrate specificities, expression patterns and new domain combinations.


  • protease;
  • evolution;
  • gene duplication;
  • domains;
  • structure