Standard Article

Transcriptional Regulation: Evolution

  1. Gregory A Wray

Published Online: 21 DEC 2007

DOI: 10.1002/9780470015902.a0006142.pub2



How to Cite

Wray, G. A. 2007. Transcriptional Regulation: Evolution. eLS. .

Author Information

  1. Duke University, Durham, North Carolina, USA

Publication History

  1. Published Online: 21 DEC 2007


Changes in transcriptional regulation can result from mutations in cis (within regulatory sequences) or trans (in the structure or expression of transcription factors). Modifications in transcription can have a profound impact on gene function and constitute an important class of evolutionary change within genomes.


  • cis-regulatory sequence;
  • enhancer;
  • polymorphism;
  • promoter;
  • transcription factor