Standard Article

Transcriptional Regulation: Evolution

  1. Gregory A Wray

Published Online: 21 DEC 2007

DOI: 10.1002/9780470015902.a0006142.pub2

eLS

eLS

How to Cite

Wray, G. A. 2007. Transcriptional Regulation: Evolution. eLS. .

Author Information

  1. Duke University, Durham, North Carolina, USA

Publication History

  1. Published Online: 21 DEC 2007

Abstract

Changes in transcriptional regulation can result from mutations in cis (within regulatory sequences) or trans (in the structure or expression of transcription factors). Modifications in transcription can have a profound impact on gene function and constitute an important class of evolutionary change within genomes.

Keywords:

  • cis-regulatory sequence;
  • enhancer;
  • polymorphism;
  • promoter;
  • transcription factor