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Cryogenic Detectors: Detection of Single Molecules

  1. Damian Twerenbold

Published Online: 15 SEP 2006

DOI: 10.1002/9780470015902.a0006203

eLS

eLS

How to Cite

Twerenbold, D. 2006. Cryogenic Detectors: Detection of Single Molecules. eLS. .

Author Information

  1. Institut de Physique, Université Neuchâtel, Neuchâtel, Switzerland

Publication History

  1. Published Online: 15 SEP 2006

Abstract

To extend the technique of mass spectrometry for analyzing large protein complexes, more sensitive detectors are required. Cryogenic detectors operate by measuring the energy deposition of a single molecule. Their detection sensitivity is independent of mass, and both the arrival time and energy of an individual molecule are measured in a MALDI-TOF mass spectrometer.

Keywords:

  • MALDI-TOF;
  • mass spectrometry;
  • detector;
  • protein complexes;
  • sensitivity;
  • cryodetector