Cryogenic Detectors: Detection of Single Molecules
Published Online: 15 SEP 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Twerenbold, D. 2006. Cryogenic Detectors: Detection of Single Molecules. eLS. .
- Published Online: 15 SEP 2006
To extend the technique of mass spectrometry for analyzing large protein complexes, more sensitive detectors are required. Cryogenic detectors operate by measuring the energy deposition of a single molecule. Their detection sensitivity is independent of mass, and both the arrival time and energy of an individual molecule are measured in a MALDI-TOF mass spectrometer.
- mass spectrometry;
- protein complexes;