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Cystic Fibrosis Transmembrane Conductance Regulator Sequences: Comparative Analysis

  1. Jian-Min Chen1,
  2. Guillaume Lecointre2,
  3. Erick Denamur3,
  4. Claude Férec4

Published Online: 15 SEP 2006

DOI: 10.1002/9780470015902.a0006227

eLS

eLS

How to Cite

Chen, J.-M., Lecointre, G., Denamur, E. and Férec, C. 2006. Cystic Fibrosis Transmembrane Conductance Regulator Sequences: Comparative Analysis. eLS. .

Author Information

  1. 1

    Etablissement Français du Sang, Brest, France

  2. 2

    Muséum National d'Histoire Naturelle, Paris, France

  3. 3

    Hôpital Robert Debré, Paris, France

  4. 4

    Université de Bretagne Occidentale, Brest, France

Publication History

  1. Published Online: 15 SEP 2006

Abstract

Information obtained by comparing cystic fibrosis transmembrane conductance regulator sequences has been used to refine the domain structure of the protein, to better understand the effects of the many mutations identified in typical and atypical cystic fibrosis patients, and to develop better animal models for cystic fibrosis studies.

Keywords:

  • cystic fibrosis transmembrane conductance regulator;
  • disease model;
  • domain structure;
  • missense mutation;
  • phylogeny