Standard Article

Kinetochore: Structure, Function and Evolution

  1. Katsumi Kitagawa

Published Online: 15 SEP 2006

DOI: 10.1002/9780470015902.a0006237

eLS

eLS

How to Cite

Kitagawa, K. 2006. Kinetochore: Structure, Function and Evolution. eLS. .

Author Information

  1. St Jude Children's Research Hospital, Tennessee, USA

Publication History

  1. Published Online: 15 SEP 2006

This is not the most recent version of the article. View current version (15 AUG 2014)

Abstract

Kinetochores are complexes of centromere DNA and proteins. Spindle microtubules bind to chromosomes at the kinetochore, and these complexes are required for accurate chromosome segregation during mitosis. The human kinetochore is a supramolecular complex of DNA and proteins that is involved in various mitotic activities.

Keywords:

  • kinetochore;
  • centromere;
  • mitosis;
  • chromosome segregation;
  • spindle checkpoint