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Interaction Networks of Proteins

  1. Shailesh V Date1,
  2. Guang Chen2

Published Online: 28 SEP 2007

DOI: 10.1002/9780470015902.a0020203



How to Cite

Date, S. V. and Chen, G. 2007. Interaction Networks of Proteins. eLS. .

Author Information

  1. 1

    University of Pennsylvania School of Medicine, PENN Center for Bioinformatics, Philadelphia, USA

  2. 2

    University of Pennsylvania, PENN Center for Bioinformatics, Philadelphia, USA

Publication History

  1. Published Online: 28 SEP 2007


Proteins are often the ultimate expression of information encoded in the DNA (deoxyribonucleic acid). Proteins interact with other proteins, nucleic acids, and a variety of small molecules to affect cellular function. Such interactions assume the form of a vast network, portions of which are activated in a spatial and temporal manner. Understanding the makeup, properties and behaviour of this network promises to reveal many important details of the biology of organisms, ultimately helping better our knowledge of molecular and biochemical events that take place at the cellular level.


  • protein-protein interactions;
  • functional interactions;
  • protein interaction networks;
  • protein-DNA regulation networks;
  • transcriptional regulatory networks;