Normal Mode Analysis Techniques in Structural Biology
Published Online: 28 SEP 2007
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Miyashita, O. and Tama, F. 2007. Normal Mode Analysis Techniques in Structural Biology. eLS. .
- Published Online: 28 SEP 2007
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Normal mode theory originates from classical mechanics and has been used in several fields such as mechanical engineering and spectroscopy. It was first applied 20 years ago to investigate dynamical properties of small biological systems. Today, due to advancement in computational techniques as well as processing power, normal mode analysis has emerged again as a very powerful method to study motions of large macromolecular machines that are critically important for sustaining most biological functions in our bodies.
- conformational changes;
- X-ray/NMR structure;
- low-resolution structure;