Standard Article

Disordered Proteins

  1. A Keith Dunker

Published Online: 28 SEP 2007

DOI: 10.1002/9780470015902.a0020213



How to Cite

Dunker, A. K. 2007. Disordered Proteins. eLS. .

Author Information

  1. Indiana University School of Medicine, Indianapolis, Indiana, USA

Publication History

  1. Published Online: 28 SEP 2007

This is not the most recent version of the article. View current version (15 SEP 2016)


Disordered proteins and disordered protein regions fail to form specific three-dimensional (3D) structure as monomers under physiological conditions, existing instead as dynamic structural ensembles. These dynamical proteins and regions often carry out biological function. Just as amino acid sequence codes for 3D structure, amino acid sequence also codes for the failure of a protein or regions to form specific structure. A major goal in the coming years will be to understand sequence-to-function relationships for disordered proteins.


  • unfolded;
  • flexible;
  • unstructured;
  • protein function