Susceptibility to Malaria, Genetics of
Published Online: 16 JUL 2007
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Berghout, J. and Gros, P. 2007. Susceptibility to Malaria, Genetics of. eLS. .
- Published Online: 16 JUL 2007
Malaria has exerted a strong, selective pressure on many genes in the human genome, leading to the development and retention of several alleles which confer a proctective advantage against blood-stage infection. Many of these polymorphisms, including sickle cell anaemia and the thalassaemias, are in the haemoglobin genes, but other mutations have been found in metabolism and immune response. Since many interacting genes are involved in the host response to malaria, animal models have been extremely useful in helping to identify and understand the host–parasite interaction.
- infectious disease;