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Susceptibility to Malaria, Genetics of

  1. Joanne Berghout,
  2. Philippe Gros

Published Online: 16 JUL 2007

DOI: 10.1002/9780470015902.a0020218

eLS

eLS

How to Cite

Berghout, J. and Gros, P. 2007. Susceptibility to Malaria, Genetics of. eLS. .

Author Information

  1. McGill University, Montreal, QC, Canada

Publication History

  1. Published Online: 16 JUL 2007

Abstract

Malaria has exerted a strong, selective pressure on many genes in the human genome, leading to the development and retention of several alleles which confer a proctective advantage against blood-stage infection. Many of these polymorphisms, including sickle cell anaemia and the thalassaemias, are in the haemoglobin genes, but other mutations have been found in metabolism and immune response. Since many interacting genes are involved in the host response to malaria, animal models have been extremely useful in helping to identify and understand the host–parasite interaction.

Keywords:

  • malaria;
  • genetics;
  • infectious disease;
  • plasmodium;
  • haemoglobin