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Amidohydrolase Superfamily

  1. Liu Aimin,
  2. Li Tingfeng,
  3. Fu Rong

Published Online: 28 SEP 2007

DOI: 10.1002/9780470015902.a0020546



How to Cite

Aimin, L., Tingfeng, L. and Rong, F. 2007. Amidohydrolase Superfamily. eLS. .

Author Information

  1. University of Mississippi Medical Center, Jackson, Mississippi, USA

Publication History

  1. Published Online: 28 SEP 2007

This is not the most recent version of the article. View current version (15 AUG 2014)


The amidohydrolase superfamily is a structure-based cluster of enzymes that contain a sturdy and versatile triosephosphate isomerase (TIM)-like β-barrel embracing a mono- or dinuclear d-block metal cofactor essential for catalysis. Up to date, it has had several thousand members catalysing a wide range of hydrolytic and nonhydrolytic metabolic reactions important in amino acid and nucleotide metabolism as well as biodegradation of agricultural and industrial compounds.


  • amidohydrolase;
  • metal cofactor;
  • TIM-barrel structural fold;
  • enzymology;
  • evolution