Radical S-adenosylmethionine (SAM) Superfamily
Published Online: 28 SEP 2007
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Farrar, C. E. and Jarrett, J. T. 2007. Radical S-adenosylmethionine (SAM) Superfamily. eLS. .
- Published Online: 28 SEP 2007
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A large superfamily of enzymes use S-adenosylmethionine (SAM) to generate high-energy carbon radicals as intermediates in a variety of metabolic and biosynthetic reactions. Despite the diverse reactions catalysed, members of the SAM radical superfamily share a similar structural topology that facilitates the mechanistically important interaction of SAM with an iron–sulfur cluster.
- iron–sulfur cluster;
- enzyme mechanism;
- protein structure