Varicella Zoster: Virus and Disease
Published Online: 15 JUL 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
McDonald, S. L. and Breuer, J. 2008. Varicella Zoster: Virus and Disease. eLS. .
- Published Online: 15 JUL 2008
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Varicella zoster virus (VZV), also known as human herpes virus 3 (HHV3), causes varicella (chicken pox) upon primary infection, establishes latency in dorsal root ganglia (DRG) and can later reactivate to cause herpes zoster (shingles). Difficulties in studying the pathogenesis of VZV; because of its high cell association and narrow host range, have been overcome through the development of the VZV severe combined immunodeficient (SCID) mouse model carrying human tissue implants. VZV is the first human herpes virus for which a live attenuated vaccine has been developed.
- varicella zoster virus;
- herpes zoster;
- human herpes virus 3