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Varicella Zoster: Virus and Disease

  1. Suzanna LR McDonald,
  2. Judith Breuer

Published Online: 15 JUL 2008

DOI: 10.1002/9780470015902.a0020715



How to Cite

McDonald, S. L. and Breuer, J. 2008. Varicella Zoster: Virus and Disease. eLS. .

Author Information

  1. Institute of Cell and Molecular Science, Bart's and the London School of Medicine and Dentisty, UK

Publication History

  1. Published Online: 15 JUL 2008

This is not the most recent version of the article. View current version (9 DEC 2014)


Varicella zoster virus (VZV), also known as human herpes virus 3 (HHV3), causes varicella (chicken pox) upon primary infection, establishes latency in dorsal root ganglia (DRG) and can later reactivate to cause herpes zoster (shingles). Difficulties in studying the pathogenesis of VZV; because of its high cell association and narrow host range, have been overcome through the development of the VZV severe combined immunodeficient (SCID) mouse model carrying human tissue implants. VZV is the first human herpes virus for which a live attenuated vaccine has been developed.


  • varicella zoster virus;
  • herpes zoster;
  • shingles;
  • chickenpox;
  • human herpes virus 3